Research Activites

Asymmetric Catalysis | Bio-coordination Chemistry

In the area of asymmetric catalysis, our emphasis is on the design of complexes with potential for weak interactions. Again, we are developing specialized phosphites and phosphines which can have specific interactions with the substrate / reagents. Our design criteria is based on the fact that asymmetric catalysis requires but a difference of a few kilocalories in the diasteromeric transition states. This could be easily provided by hydrogen bonding and other weak interactions. Specific information would be posted below.


Asymmetric Catalysis

Asymmetric Catalysis has emerged as one of the greatest challenges in chemical synthesis. While it is generally possible to make and break various bonds with ease, it is not always possible to do this in an asymmetric fashion. The transition states leading to the formation of two enantiomers are usually diasteroisomers. To achieve a enantiomeric excess (e.e) of 99 % for a reaction run at room temperature, the difference in energy between the two transition states has to be about 3 Kcals /mol. In most instances, "steric effects" have been used to tilt the balance in favor of one transition state over the other. Less explored have been the use of hydrogen bonding and hemilabile ligands. We are developing specialized phosphites and phosphines which can have specific interactions with the substrate / reagents via hydrogen bond donors or acceptors.
People working in this area in our group

Arun Kumar