Medicinal Inorganic Chemistry
Our research interest is mainly focused on designing drug capped fluorescent nanomaterials for selectively target important organelles in cells and bacteria that has critical role in disease and therapy. Our strategey is to selectively deliver drug molecules at the target site with the help of internal or external stimuli (such as light, heat, bioreductants and pH). We are also interested in designing targeted photoactivatable metal complexes and study their mechanism of action. We study the interaction of anticancer metal complexes with important biomolecules such as DNA, RNA and proteins in order to understand their mode of action and toxicities. We further study the photocytotoxicites of metal complexes against different surface cancer cell lines, particularly resistant cell lines.
V. Venkatesh, N. K. Mishra, I. R. Canelón, R. R. Vernooij, H. Shi, J. P. C. Coverdale, A. Habtemariam, S. Verma, and P. J. SadlerJ. Am. Chem. Soc., 2017, 139, 5656–5659.
Mitochondria-targeted spin-labelled luminescent iridium anticancer complexesV. Venkatesh, R. B.-Martin, C. J. Wedge, I. R. Canelón, C. S.-Cano, J. Song, J. P. C. Coverdale, P. Zhang, G. J. Clarkson, A. Habtemariam, S.W. Magennis, R. J. Deeth and P. J. SadlerChem. Sci., 2017, 8, 8271–8278.V. Venkatesh, C. J. Wedge, I. R. Canelón, A. Habtemariam and P. J. SadlerDalton Trans., 2016, 45, 13034–13037.S. Kandambeth, V. Venkatesh, D. B. Shinde, S. Kumari, A. Halder, S. Verma, and R. BanerjeeNature Commun., 2015, 6, 6786.Evolution of an adenine-copper cluster to a cuboidal framework: snapshots of its solution phase ripening and gas adsorption propertiesV. Venkatesh, P. Pachfule, R. Banerjee and S. VermaChem. Eur. J., 2014, 20, 12262–12268.V. Venkatesh, A. Shukla, S. Sivakumar and S. Verma.ACS Appl. Mater. Interfaces, 2014, 6, 2185–2191.Biotin interaction with human erythrocytes: contact on membrane surface and formation of self-assembled ﬁbrous structures.K. B. Joshi, V. Venkatesh and S. VermaChem. Commun., 2010, 46, 3890–3892.